Dec 3, 2017 · Gibson CM, et al. "Prevention of bleeding in patients with AF undergoing PCI". The New England Journal of Medicine. 2016. epub 2016-11-14:1-12. PubMed • Full text • PDF 1Clinical Question 2Bottom Line 3Major Points 4Guidelines 5Design 6Population 6.1Inclusion Criteria 6.2Exclusion Criteria 6.3Baseline Characteristics 7Interventions 8Outcomes 8.1Primary Outcomes 8.2Secondary Outcomes 8.3Exploratory Analyses 8.4Subgroup Analysis 8.5Adverse Events 9Criticisms 10Funding 11Further Reading Clinical QuestionJul 2, 2020 · Published in 2019, PARAGON-HF was a randomized controlled trial that enrolled 4,822 patients with NYHA class %ge;II symptoms, preserved EF (defined as ≥45%), elevated natriuretic peptide level, and evidence of structural heart disease. Participants were randomized to sacubitril-valsartan (target dose 97/103mg twice daily) or valsartan (target ... Oct 29, 2020 · Published in 2018, the Anticoagulation Therapy in Selected Cancer Patients at Risk of Recurrence of Venous Thromboembolism (SELECT-D) trial was a pilot study which randomized 406 patients with known cancer and concurrent VTE in a 1:1 fashion to either rivaroxaban or dalteparin. Follow-up imaging was performed as clinically indicated. Apr 29, 2021 · The New England Journal of Medicine. 2018. 379:2307-2318. PubMed • Full text • PDF. Contents. 1 Clinical Question; 2 Bottom Line; ... About Wiki Journal Club ... Dec 3, 2017 · Published in 2000, this single-center study by Kress, et al., randomized 128 intubated ICU patients to either daily interruptions of sedation (commonly known as "sedation holidays") or interruptions when thought to be appropriate by the intensivist. Of note, the daily sedation interruptions included evaluation by the clinician to assess for ... Nov 5, 2020 · The 2017 Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) trial randomized patients with established atherosclerotic disease on background moderate- or high-intensity statin therapy (70% high intensity) to the PCSK9 inhibitor evolocumab versus placebo and assessed for a primary outcome of ... WikiJournalClub:About. Wiki Journal Club ( WJC) is a collaborative website providing concise summaries of landmark clinical trials. All of our content is freely accessible. Browse the offerings, but consider contributing as well. The more you contribute, the more successful the website will be.Oct 13, 2022 · Published in 2021, EMPEROR-Preserved trial randomized about 6,000 patients with NYHA class II-IV symptoms, LVEF >40% (i.e., HFmrEF and HFpEF), and NT-proBNP >300 pg/mL (no AF) or >900 pg/mL (AF) regardless of diabetes history to the SGLT2i empagliflozin or placebo. With 26.2 months of follow-up, empagliflozin was associated with a lower risk of ... May 22, 2014 · Based upon the results of RACE II, very stringent HR control is not necessary in many physically active patients with AF who are minimally symptomatic. A more lenient rate control strategy offers the advantages of less medication and fewer outpatient visits to achieve HR control. Guidelines. Apr 29, 2021 · The New England Journal of Medicine. 2018. 379:2307-2318. PubMed • Full text • PDF. Contents. 1 Clinical Question; 2 Bottom Line; ... About Wiki Journal Club ... Jul 3, 2018 · The 2014 Albumin Italian Outcome Sepsis (ALBIOS) trial randomized 1,818 patients with severe sepsis or septic shock at 100 Italian ICUs in an unblinded fashion to albumin or no albumin. Those in the albumin group received an initial bolus and then daily administrations of IV albumin to maintain the serum albumin ≥3 g/dL (≥30 g/L). Feb 20, 2021 · CONSENSUS (1987) randomized 253 patients with HFrEF and NYHA class IV symptoms to enalapril or placebo in addition to standard medical therapy. The intervention group had a 40% reduction in mortality at 6 months with a NNT of 6. A mortality benefit was subsequently demonstrated by the SOLVD trial (1991) in patients with moderate HFrEF. Guidelines. Dec 3, 2017 · The 2013 Moderate Pulmonary Embolism Treated with Thrombolysis (MOPETT) trial randomized 121 patients at a single center with moderate PE to either low-dose tPA or control in an unblinded fashion. All patients received anticoagulation with LMWH or UFH as well as warfarin. Few patients had RV enlargement (21%) or RV dysfunction (6%), two ... Feb 6, 2020 · The New England Journal of Medicine.' 2001;345(19):1359-1367. ↑ Finfer S, et al. "Hypoglycemia and risk of death in critically ill patients." The New England Journal of Medicine. (2012)367.12:1108. ↑ Inzucchi SE, et al. "Glucose Control in the ICU — How Tight Is Too Tight?" N Engl J Med. 2009;360:1346-1349 Dec 3, 2017 · The 2009 Platelet Inhibition and Patient Outcomes (PLATO) trial randomized 18,624 patients with ACS (37.5% with STEMI) to ticagrelor or clopidogrel, in addition to standard care. At 12 months, the ticagrelor group had lower rates of CV death, MI, or stroke than clopidogrel (9.8% vs. 11.7%) and all-cause mortality (4.5% vs. 5.9%). Feb 6, 2020 · The New England Journal of Medicine.' 2001;345(19):1359-1367. ↑ Finfer S, et al. "Hypoglycemia and risk of death in critically ill patients." The New England Journal of Medicine. (2012)367.12:1108. ↑ Inzucchi SE, et al. "Glucose Control in the ICU — How Tight Is Too Tight?" N Engl J Med. 2009;360:1346-1349 Oct 6, 2022 · Major Points. Chlorthalidone's efficacy and safety in patients with advanced chronic kidney disease was unknown. The CLICK trial demonstrated that use of chlorthalidone improves blood pressure in this population. N=160. Placebo (n=79) Enrollment: Mean follow-up: Population. Nov 5, 2020 · CARAVAGGIO enrolled 1,170 patients with cancer-associated VTE, randomizing to either apixaban or dalteparin for 6 months. Chief eligibility criteria included symptomatic or incidental VTE, active or recent malignancy, and absence of brain lesions. The primary outcome was objectively confirmed recurrent VTE at 6 months from randomization, and ... WikiJournalClub:List of landmark papers. Landmark papers are highly influential papers that have substantially changed the practice of medicine or provided the missing evidence to support current practices. Here is our evolving list of landmark papers, organized by subspecialty.Feb 4, 2023 · There was a need for replication of SPRINT. Published in 2021, the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial randomized 8,511 Han Chinese adults (i.e., excluding Chinese minority groups) with hypertension to intensive BP control (SBP 110 to <130 mm Hg) or standard BP control (SBP 130 to <150 mm Hg ... Feb 9, 2021 · The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial 4 (EAST-AFNET 4) randomized patients with recently diagnosed AF (defined as diagnosed ≤12 months before enrollment) to early rhythm control vs. usual care. The patients were similar in age to those in the AFFIRM trial, but started on treatment earlier. May 31, 2021 · The 2019 Novel START trial randomized 675 adults with mild asthma to 1 of 3 arms in an open-label fashion: 1. Budesonide+formoterol PRN (ICS+LABA PRN), 2. Albuterol PRN (SABA PRN), or 3. Budesonide BID+albuterol PRN (ICS BID+SABA PRN). There was a similar number of asthma exacerbations per patient per year between the ICS+LABA PRN and ICS BID ... Dec 3, 2017 · Published in 2000, this single-center study by Kress, et al., randomized 128 intubated ICU patients to either daily interruptions of sedation (commonly known as "sedation holidays") or interruptions when thought to be appropriate by the intensivist. Of note, the daily sedation interruptions included evaluation by the clinician to assess for ... Dec 3, 2017 · The New England Journal of Medicine. 2013;369(22):2093-2104. ↑ January CT, et al. "2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary." Circulation. 2014:epub April. ↑ 5.0 5.1 5.2 "Correspondence: Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation." N Engl J Med. 2011;365:2333-2335 Apr 19, 2023 · Agnelli G, et al. "Apixaban for extended treatment of venous thromboembolism". The New England Journal of Medicine. 2013. 368(8):699-708. PubMed • Full text • PDF rancho bernardo san diego ca
Using the same software that powers Wikipedia, the trio created Wiki Journal Club. Members consist of doctors, pharmacists, and medical and pharmacy students who write reviews distilling pieces of medical literature into bite-size morsels. Each entry includes links to the actual article, PubMed entry and PDF.Feb 12, 2021 · Williams B, et al. "Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial". WikiJournalClub:About. Wiki Journal Club ( WJC) is a collaborative website providing concise summaries of landmark clinical trials. All of our content is freely accessible. Browse the offerings, but consider contributing as well. The more you contribute, the more successful the website will be.Dec 14, 2017 · ODYSSEY OUTCOMES is an ongoing trial designed specifically to investigate the effects of alirocumab on cardiovascular endpoints over long-term follow up. Guidelines. Focused Update of the 2016 ACC Non-Statin Guidelines [5] If a decision is made to proceed with the addition of non-statin therapy to maximally tolerated statin therapy in patients ... Feb 25, 2021 · Mehta SR, et al. "Complete Revascularization with Multivessel PCI for Myocardial Infarction". The New England Journal of Medicine. 2019. 381(15):1411-1421. PubMed • Full text • PDF WikiJournalClub:List of landmark papers. Landmark papers are highly influential papers that have substantially changed the practice of medicine or provided the missing evidence to support current practices. Here is our evolving list of landmark papers, organized by subspecialty.Jan 3, 2020 · The 2013 Clopidogrel in High-risk patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial randomized 5,170 Chinese patients with high-risk TIA or minor ischemic stroke within 24 hours of symptom onset to either combination aspirin/clopidogrel or aspirin alone. In the combination group, aspirin was continued for 21 days; all other ... Sep 6, 2018 · From Wiki Journal Club. ... The Journal of the American Medical Association. 2011. 305(6):569-575. PubMed • Full text • PDF. Contents. 1 Clinical Question; Jun 1, 2018 · NSAIDs are among the most widely prescribed drugs in the world. NSAIDs work by inhibiting cyclooxygenase (COX) which reduces pain and inflammation through inhibition of prostaglandins. Prostaglandins also play an important role in maintaining the gastric mucosa and promoting vasodilation. Inhibition of COX-2 is primarily responsible for pain ... Jun 1, 2018 · NSAIDs are among the most widely prescribed drugs in the world. NSAIDs work by inhibiting cyclooxygenase (COX) which reduces pain and inflammation through inhibition of prostaglandins. Prostaglandins also play an important role in maintaining the gastric mucosa and promoting vasodilation. Inhibition of COX-2 is primarily responsible for pain ... box box
Sep 6, 2018 · From Wiki Journal Club. ... The Journal of the American Medical Association. 2011. 305(6):569-575. PubMed • Full text • PDF. Contents. 1 Clinical Question; Jun 1, 2022 · Days of missed work for participant. 5.26 vs 8.73, RR 0.63 (0.51 to 0.77) Days of missed work for caregiver. 1.33 vs 2.04, RR 0.66 (0.48 to 0.91) A subgroup analysis was done for patients with an appendicolith: Any hospitalization after index treatment. 32% vs 5%, RR 6.36 (3.13 to 12.90) Days in hospital after index treatment. Jun 8, 2021 · Meyer G, et al. "Fibrinolysis for patients with intermediate-risk pulmonary embolism". The New England Journal of Medicine. 2014. 370(15):1402-1411. PubMed • Full text • PDF Jul 12, 2020 · Whether early NM blockade plays a role in modern ARDS management is unknown. In 2019, the multicenter Reevaluation of Systemic Early Neuromuscular Blockade (ROSE) trial sought to re-test the findings of ACURASYS using modern protocols. It was run by the NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. Apr 12, 2023 · Fidaxomicin has been shown to reduce recurrence rate as compared to vancomycin (16.9% vs 29.2%; P = 0.048). [3] However, its cost-effectiveness has been debated. [4] As discussed in a recent review, the recurrence rate associated with fidaxomicin treatment remains suboptimal (>10%). [5] Apr 12, 2023 · Fidaxomicin has been shown to reduce recurrence rate as compared to vancomycin (16.9% vs 29.2%; P = 0.048). [3] However, its cost-effectiveness has been debated. [4] As discussed in a recent review, the recurrence rate associated with fidaxomicin treatment remains suboptimal (>10%). [5] Feb 9, 2021 · The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial 4 (EAST-AFNET 4) randomized patients with recently diagnosed AF (defined as diagnosed ≤12 months before enrollment) to early rhythm control vs. usual care. The patients were similar in age to those in the AFFIRM trial, but started on treatment earlier. Jump to navigationJump to search The following are articles in Category:Usable articles. Allergy and Immunology Asthma EXTRA(2011): Omalizumab in severe allergic asthma Cardiology Acute Coronary Syndrome ACT(2011): Acetylcysteine with IV contrast ATLAS ACS-2, TIMI 51(2012): Rivaroxaban after ACS CAPRICORN(2001): Carvedilol post-MI with HFrEFWikiJournalClub:About. Wiki Journal Club ( WJC) is a collaborative website providing concise summaries of landmark clinical trials. All of our content is freely accessible. Browse the offerings, but consider contributing as well. The more you contribute, the more successful the website will be.gabe's store
Dec 3, 2017 · Published in 2000, this single-center study by Kress, et al., randomized 128 intubated ICU patients to either daily interruptions of sedation (commonly known as "sedation holidays") or interruptions when thought to be appropriate by the intensivist. Of note, the daily sedation interruptions included evaluation by the clinician to assess for ... Dec 3, 2017 · The 2013 Moderate Pulmonary Embolism Treated with Thrombolysis (MOPETT) trial randomized 121 patients at a single center with moderate PE to either low-dose tPA or control in an unblinded fashion. All patients received anticoagulation with LMWH or UFH as well as warfarin. Few patients had RV enlargement (21%) or RV dysfunction (6%), two ... Apr 5, 2018 · Published in 2018, the Saline against Lactated Ringer’s or Plasma-Lyte in the Emergency Department (SALT-ED) Trial aimed to compare initial resuscitation of ED patients with balanced crystalloids vs. isotonic crystalloid in a pragmatic setting. A single center enrolled 13,347 adults in the ED thought to need additional fluids after a 500 mL ... Dec 3, 2017 · The Coronary Artery Revascularization Prophylaxis (CARP) trial compared preoperative coronary artery revascularization to no revascularization. Among 5,859 patients scheduled for elective vascular surgery, 1,190 high risk patients underwent coronary angiogram. Patients with significant LM disease, LVEF ≤20%, or severe aortic stenosis were ... Sep 4, 2018 · Journal of the American College of Cardiology. 2014;epublished 2014-09-23. Accessed 2014-09-24. ↑ O'Gara PT, et al. "2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines." May 18, 2023 · As detailed in Figure S6, the authors estimated that 181 primary efficacy events were prevented for each 10,000 patients treated with rivaroxaban for 1 year. [6] Taken together, COMPASS and VOYAGER-PAD provides some evidence for the use of low-dose rivaroxaban in PAD. Guidelines. As of April 2023, no guidelines have been published that reflect ... Dec 3, 2017 · The Coronary Artery Revascularization Prophylaxis (CARP) trial compared preoperative coronary artery revascularization to no revascularization. Among 5,859 patients scheduled for elective vascular surgery, 1,190 high risk patients underwent coronary angiogram. Patients with significant LM disease, LVEF ≤20%, or severe aortic stenosis were ... 1Clinical Question 2Bottom Line 3Major Points 4Guidelines 5Design 6Population 6.1Inclusion Criteria 6.2Exclusion Criteria 6.3Baseline Characteristics 7Interventions 8Outcomes 8.1Primary Outcomes 8.2Secondary Outcomes 8.3Exploratory Analyses 8.4Subgroup Analysis 8.5Adverse Events 9Criticisms 10Funding 11Further Reading Clinical QuestionOct 8, 2019 · The Oral Versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial was a multicenter, parallel group, 1:1 randomized, open label, non-inferiority trial comparing IV to oral therapy in 1054 patients. The investigators followed patients for 1 year for treatment failure, and the statistical design prespecified a non-inferiority ... Aug 10, 2020 · The New England Journal of Medicine. 2018. 379:2199-2208. PubMed • Full text • PDF. Contents. 1 Clinical Question; 2 Bottom Line; ... About Wiki Journal Club ... Aug 1, 2020 · CEA reduces the 5-year risk of death or stroke by 29% among patients with symptomatic high-moderate (50-69%) carotid stenosis. Prior studies had demonstrated the benefit of carotid endarterectomy (CEA) in patients with severe carotid stenosis, but NASCET was the first large, well-designed trial to study CEA in patients with low-moderate (<50% ... Jan 6, 2021 · Curiously, the DNase+placebo group had might higher proportion of surgical referral than the double placebo group (39% vs. 16%). The proportion of serious adverse events was similar in each group. MIST2 provides initial evidence for the use of fibrinolytics plus DNase in management of empyemas, but does not support routine use of either ... Apr 19, 2023 · Agnelli G, et al. "Apixaban for extended treatment of venous thromboembolism". The New England Journal of Medicine. 2013. 368(8):699-708. PubMed • Full text • PDF Nov 5, 2020 · The 2017 Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) trial randomized patients with established atherosclerotic disease on background moderate- or high-intensity statin therapy (70% high intensity) to the PCSK9 inhibitor evolocumab versus placebo and assessed for a primary outcome of ... Nov 5, 2020 · CARAVAGGIO enrolled 1,170 patients with cancer-associated VTE, randomizing to either apixaban or dalteparin for 6 months. Chief eligibility criteria included symptomatic or incidental VTE, active or recent malignancy, and absence of brain lesions. The primary outcome was objectively confirmed recurrent VTE at 6 months from randomization, and ... Feb 28, 2019 · FAIR-HF demonstrated IV iron replacement is a low-risk intervention that can improve symptom burden and quality of life in a relatively broad population of patients with HFrEF. Based on the findings of FAIR-HF, assessment and treatment for iron deficiency even in the absence of anemia is now routinely practiced in patients with heart failure ... google weather app
Dec 3, 2017 · The Coronary Artery Revascularization Prophylaxis (CARP) trial compared preoperative coronary artery revascularization to no revascularization. Among 5,859 patients scheduled for elective vascular surgery, 1,190 high risk patients underwent coronary angiogram. Patients with significant LM disease, LVEF ≤20%, or severe aortic stenosis were ... Nov 5, 2020 · The 2017 Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) trial randomized patients with established atherosclerotic disease on background moderate- or high-intensity statin therapy (70% high intensity) to the PCSK9 inhibitor evolocumab versus placebo and assessed for a primary outcome of ... Aug 10, 2018 · CASTLE-AF adds to emerging evidence suggesting that catheter ablation is not only associated with improved rhythm control in patients with AF and symptomatic systolic heart failure, but it is also associated with improved cardiovascular outcomes in this population, with lower rates of death and hospitalization for heart failure. Sep 14, 2020 · Bonaca MP, et al. "Long-term use of ticagrelor in patients with prior myocardial infarction". The New England Journal of Medicine. 2015. 372(19):1791-1800. PubMed • Full text • PDF Feb 20, 2021 · CONSENSUS (1987) randomized 253 patients with HFrEF and NYHA class IV symptoms to enalapril or placebo in addition to standard medical therapy. The intervention group had a 40% reduction in mortality at 6 months with a NNT of 6. A mortality benefit was subsequently demonstrated by the SOLVD trial (1991) in patients with moderate HFrEF. Guidelines. Apr 20, 2017 · The 2008 European Cooperative Acute Stroke Study III (ECASS III) demonstrated a benefit of intravenous alteplase beyond the conventional 3-hour time window established in the NINDS trial (1995), effectively extending the window for alteplase to 4.5 hours. The primary outcome was disability at 3 months, and ECASS III found a greater proportion ... Nov 22, 2020 · The 2008 Vasopressin and Septic Shock Trial (VASST) randomized 779 patients with septic shock resistant to fluids being treated with low-dose norepinephrine to norepinephrine or low-dose vasopressin to maintain a MAP of 65-75 mmHg. Open label vasopressors were added as needed. Jun 8, 2021 · Meyer G, et al. "Fibrinolysis for patients with intermediate-risk pulmonary embolism". The New England Journal of Medicine. 2014. 370(15):1402-1411. PubMed • Full text • PDF Oct 6, 2022 · Major Points. Chlorthalidone's efficacy and safety in patients with advanced chronic kidney disease was unknown. The CLICK trial demonstrated that use of chlorthalidone improves blood pressure in this population. N=160. Placebo (n=79) Enrollment: Mean follow-up: Population. Jun 1, 2022 · Days of missed work for participant. 5.26 vs 8.73, RR 0.63 (0.51 to 0.77) Days of missed work for caregiver. 1.33 vs 2.04, RR 0.66 (0.48 to 0.91) A subgroup analysis was done for patients with an appendicolith: Any hospitalization after index treatment. 32% vs 5%, RR 6.36 (3.13 to 12.90) Days in hospital after index treatment. Apr 22, 2021 · Adult aged ≥18 years with T2DM meeting ADA 2010 DM definition [1] CKD, defined by 1 of the following: Persistent albuminuria 30 to <300 mg/g, eGFR 25-59 mL/min/1.73 m 2, and known diabetic retinopathy. Persistent albuminuria 300-5000 mg/g and eGFR 25-74 mL/min/1.73 m. Maximum dose ACE-inhibitor or/ARB, with run-in details on pg 14 of the ... Oct 8, 2019 · The Oral Versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial was a multicenter, parallel group, 1:1 randomized, open label, non-inferiority trial comparing IV to oral therapy in 1054 patients. The investigators followed patients for 1 year for treatment failure, and the statistical design prespecified a non-inferiority ... Dec 3, 2017 · The 2013 Moderate Pulmonary Embolism Treated with Thrombolysis (MOPETT) trial randomized 121 patients at a single center with moderate PE to either low-dose tPA or control in an unblinded fashion. All patients received anticoagulation with LMWH or UFH as well as warfarin. Few patients had RV enlargement (21%) or RV dysfunction (6%), two ... bstationApr 22, 2021 · Adult aged ≥18 years with T2DM meeting ADA 2010 DM definition [1] CKD, defined by 1 of the following: Persistent albuminuria 30 to <300 mg/g, eGFR 25-59 mL/min/1.73 m 2, and known diabetic retinopathy. Persistent albuminuria 300-5000 mg/g and eGFR 25-74 mL/min/1.73 m. Maximum dose ACE-inhibitor or/ARB, with run-in details on pg 14 of the ... WikiJournalClub:About. Wiki Journal Club ( WJC) is a collaborative website providing concise summaries of landmark clinical trials. All of our content is freely accessible. Browse the offerings, but consider contributing as well. The more you contribute, the more successful the website will be.Mar 27, 2019 · Published in 2016, the Artificial Kidney Initiation in Kidney Injury (AKIKI) trial randomized patients to received early (n=311) or delayed RRT (n=308). The primary outcome was overall survival at day 60. Early RRT did not reduce mortality as compared to delayed RRT (48.5% vs. 49.7%; P=0.79). There was a significant increase in catheter-related ... Dec 14, 2017 · ODYSSEY OUTCOMES is an ongoing trial designed specifically to investigate the effects of alirocumab on cardiovascular endpoints over long-term follow up. Guidelines. Focused Update of the 2016 ACC Non-Statin Guidelines [5] If a decision is made to proceed with the addition of non-statin therapy to maximally tolerated statin therapy in patients ... Dec 24, 2018 · The Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes (RABBIT 2) trial compared the efficacy and safety of basal-bolus insulin regimen versus SSI for glycemic control of non-critically ill inpatients with T2DM who were insulin-naive. Patients treated with basal-bolus insulin had a ... Apr 22, 2021 · Adult aged ≥18 years with T2DM meeting ADA 2010 DM definition [1] CKD, defined by 1 of the following: Persistent albuminuria 30 to <300 mg/g, eGFR 25-59 mL/min/1.73 m 2, and known diabetic retinopathy. Persistent albuminuria 300-5000 mg/g and eGFR 25-74 mL/min/1.73 m. Maximum dose ACE-inhibitor or/ARB, with run-in details on pg 14 of the ... Aug 1, 2020 · CEA reduces the 5-year risk of death or stroke by 29% among patients with symptomatic high-moderate (50-69%) carotid stenosis. Prior studies had demonstrated the benefit of carotid endarterectomy (CEA) in patients with severe carotid stenosis, but NASCET was the first large, well-designed trial to study CEA in patients with low-moderate (<50% ... Oct 29, 2020 · Published in 2018, the Anticoagulation Therapy in Selected Cancer Patients at Risk of Recurrence of Venous Thromboembolism (SELECT-D) trial was a pilot study which randomized 406 patients with known cancer and concurrent VTE in a 1:1 fashion to either rivaroxaban or dalteparin. Follow-up imaging was performed as clinically indicated. Oct 29, 2020 · Published in 2018, the Anticoagulation Therapy in Selected Cancer Patients at Risk of Recurrence of Venous Thromboembolism (SELECT-D) trial was a pilot study which randomized 406 patients with known cancer and concurrent VTE in a 1:1 fashion to either rivaroxaban or dalteparin. Follow-up imaging was performed as clinically indicated. Building a Modern Journal Club: The Wiki Journal Club Experience. Building a Modern Journal Club: The Wiki Journal Club Experience J Grad Med Educ. 2015 Sep;7(3):341-3. doi: 10.4300/JGME-D-14-00488.1. Authors Timothy B Plante, David J Iberri, Emily L Coderre. PMID: 26457137 ...Dec 3, 2017 · The New England Journal of Medicine. 2013;369(22):2093-2104. ↑ January CT, et al. "2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary." Circulation. 2014:epub April. ↑ 5.0 5.1 5.2 "Correspondence: Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation." N Engl J Med. 2011;365:2333-2335 Journal Club for iPhone/Android. from Peripheral Brain, LLC. Landmark trials at your fingertips. Summarized by physicians. Share articles with colleagues. Instantly sync for new summaries. Dec 3, 2017 · The Coronary Artery Revascularization Prophylaxis (CARP) trial compared preoperative coronary artery revascularization to no revascularization. Among 5,859 patients scheduled for elective vascular surgery, 1,190 high risk patients underwent coronary angiogram. Patients with significant LM disease, LVEF ≤20%, or severe aortic stenosis were ... Oct 6, 2022 · Major Points. Chlorthalidone's efficacy and safety in patients with advanced chronic kidney disease was unknown. The CLICK trial demonstrated that use of chlorthalidone improves blood pressure in this population. N=160. Placebo (n=79) Enrollment: Mean follow-up: Population. circle crop image
Oct 8, 2019 · The Oral Versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial was a multicenter, parallel group, 1:1 randomized, open label, non-inferiority trial comparing IV to oral therapy in 1054 patients. The investigators followed patients for 1 year for treatment failure, and the statistical design prespecified a non-inferiority ... Oct 13, 2022 · Published in 2021, EMPEROR-Preserved trial randomized about 6,000 patients with NYHA class II-IV symptoms, LVEF >40% (i.e., HFmrEF and HFpEF), and NT-proBNP >300 pg/mL (no AF) or >900 pg/mL (AF) regardless of diabetes history to the SGLT2i empagliflozin or placebo. With 26.2 months of follow-up, empagliflozin was associated with a lower risk of ... Oct 13, 2022 · Published in 2021, EMPEROR-Preserved trial randomized about 6,000 patients with NYHA class II-IV symptoms, LVEF >40% (i.e., HFmrEF and HFpEF), and NT-proBNP >300 pg/mL (no AF) or >900 pg/mL (AF) regardless of diabetes history to the SGLT2i empagliflozin or placebo. With 26.2 months of follow-up, empagliflozin was associated with a lower risk of ... Dec 3, 2017 · Published in 2000, this single-center study by Kress, et al., randomized 128 intubated ICU patients to either daily interruptions of sedation (commonly known as "sedation holidays") or interruptions when thought to be appropriate by the intensivist. Of note, the daily sedation interruptions included evaluation by the clinician to assess for ... Dec 3, 2017 · Two randomized controlled trials in 2002 (Bernard et al. [1] and HACA) demonstrated a survival and neurologic benefit with therapeutic hypothermia (now called targeted temperature management, or TTM) with goal of 32-34°C in patients experiencing out-of-hospital VF or pulseless VT arrest. The AHA guidelines now recommend TTM for comatose ... Sep 4, 2018 · Journal of the American College of Cardiology. 2014;epublished 2014-09-23. Accessed 2014-09-24. ↑ O'Gara PT, et al. "2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines." Jan 25, 2020 · The Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial enrolled 518 patients with complicated intraabdominal infections who achieved surgical source control. Patients were randomized to 3-5 days of antibiotics (experimental arm) or continuation of antibiotics for a maximum of 10 days, with cessation of antibiotics 2 days after ... Dec 14, 2017 · Boden WE, et al. "Optimal medical therapy with or without PCI for stable coronary disease". The New England Journal of Medicine. 2007. 356:1503-16. PubMed • Full text • PDF Feb 9, 2021 · The Early Treatment of Atrial Fibrillation for Stroke Prevention Trial 4 (EAST-AFNET 4) randomized patients with recently diagnosed AF (defined as diagnosed ≤12 months before enrollment) to early rhythm control vs. usual care. The patients were similar in age to those in the AFFIRM trial, but started on treatment earlier. dimension 404
Jun 8, 2021 · Meyer G, et al. "Fibrinolysis for patients with intermediate-risk pulmonary embolism". The New England Journal of Medicine. 2014. 370(15):1402-1411. PubMed • Full text • PDF May 31, 2021 · The 2019 Novel START trial randomized 675 adults with mild asthma to 1 of 3 arms in an open-label fashion: 1. Budesonide+formoterol PRN (ICS+LABA PRN), 2. Albuterol PRN (SABA PRN), or 3. Budesonide BID+albuterol PRN (ICS BID+SABA PRN). There was a similar number of asthma exacerbations per patient per year between the ICS+LABA PRN and ICS BID ... 1Clinical Question 2Bottom Line 3Major Points 4Guidelines 5Design 6Population 6.1Inclusion Criteria 6.2Exclusion Criteria 6.3Baseline Characteristics 7Interventions 8Outcomes 8.1Primary Outcomes 8.2Secondary Outcomes 8.3Exploratory Analyses 8.4Subgroup Analysis 8.5Adverse Events 9Criticisms 10Funding 11Further Reading Clinical QuestionApr 22, 2021 · Adult aged ≥18 years with T2DM meeting ADA 2010 DM definition [1] CKD, defined by 1 of the following: Persistent albuminuria 30 to <300 mg/g, eGFR 25-59 mL/min/1.73 m 2, and known diabetic retinopathy. Persistent albuminuria 300-5000 mg/g and eGFR 25-74 mL/min/1.73 m. Maximum dose ACE-inhibitor or/ARB, with run-in details on pg 14 of the ...